Dermatitis Herpetiformis is an autoimmune disease characterized by:

  • clinically – a vesicular and pruritic eruption;
  • histologically – granular IgA deposits on the papillary dermis;
  • frequently associated to gluten-sensitive enteropathy;
  • genetic determinism.

Dermatitis herpetiformis can be associated to some autoimmune forms:

  • endocrine disorders: thyroid conditions, insulin dependent diabetes mellitus (IDDM), Addison’s disease;
  • collagenases: Sjogren’s syndrome, systemic lupus erythematosus;
  • cutaneous disorders: vitiligo, alopecia areata.

Medical and Social Relevance:

  • onset at the peak productivity age (40-50 years old);
  • genetic predisposition: 4.5-6.5% of DH patients have 1st degree relatives suffering from DH and an even higher percentage have relatives who suffer from gluten-sensitive enteropathy.

Key Clinical Symptoms and Signs:

  • polymorphic eruptions made up of vesicles, papules, erosions, crusts, often located on the extensor surfaces of the large joints, scalp, face or trunk. Skin lesions are often herpetiform grouped.


The dermatological conditions most frequently treated in the Laurus Medical network are: